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Nanobots could destroy nerve agents by harnessing the power of enzymes

Posted on 29th August 2018 at 12:09pm

USA: Nanobots are closer than ever to becoming a reality, with possible applications in medicine, manufacturing, robotics and fluidics. Now, scientists report developing nanobot pumps that destroy nerve agents, while simultaneously administering an antidote.

A 3-D illustration of an organophosphate compound. Researchers are developing nanobots that can neutralise organophosphate nerve agents, by harnessing the power of enzymes (Foxterrier2005/123rf)

According to Ayusman Sen, PhD, the project's principal investigator, this study arose from more general research aimed at making nanobots from enzymes. "We have been looking at how to convert chemical energy into motion," he says. "We take the energy that's generated from catalytic reactions to cause the motion of enzymes."

To make his nanobots, Sen and his group at The Pennsylvania State University used enzymes found in nature; these proteins help specific chemical reactions occur, converting a reactant (raw material) into a product.

The realisation that enzymes can move when catalysing a reaction is a relatively new discovery. Previously, scientists thought that these proteins drifted along in the cytoplasm of the cell by passive diffusion, encountering their reactants and other enzymes by more-or-less chance interactions.

However, Sen and others have recently shown that when enzymes catalyse a reaction, they move. Researchers still aren't sure how this motion occurs, but it is likely to involve a change in the shape of the enzyme upon catalysis.

Sen's group has shown that these proteins can even swim along a path toward higher levels of reactant. These features make enzymes an attractive material for developing nanobots.

"If we take enzymes and anchor them to a surface so they cannot move, and we give them their reactant, they end up pumping the fluid surrounding them," Sen says. "So they act as miniature fluid pumps that can be used for a variety of applications."

Sen and his colleagues made nanobots to neutralise organophosphates, a class of nerve agents. Exposure to these chemicals during military combat or terrorist attacks can cause permanent neurological damage, and in some cases, death.

An enzyme, called organophosphorus acid anhydrolase, can destroy these nerve agents. The researchers immobilised this enzyme on a gel that also contained an antidote. Exposure to organophosphates activates the enzyme. "The enzyme actively pumps in the organosphosphate compound and destroys it, and at the same time pumps out an antidote," Sen says. Importantly, the system requires no external power source because the enzyme is fuelled by the organophosphate reactant.

The nanobot pumps might someday be incorporated into protective clothing for the military or first responders, Sen says.

The researchers presented their results at the 256th National Meeting & Exposition of the American Chemical Society (ACS).

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